রবিবার, ২ জুন, ২০১৩

Pawsitively Pets: Romeo - Adoptable Cat in Texas Needs Forever ...

This week, I am featuring a sweet kitty named Romeo. He was also in one of the front cages when I went to pick up Honey Delite from the Williamson County Animal Shelter, so he's been there for awhile now. I remember a young couple oooh-ing and aaah-ing over him while I was there. The man kept talking about how cool Romeo was, but the lady didn't seem convinced. Don't know what she was thinking! Romeo was a sweetheart!
Romeo is a 4 year old boy kitty that is neutered and is up to date on all of his shots. He is located near Austin, TX just outside of Round Rock in a kill shelter. He is also FIV positive so he really needs someone to look after him. FIV positive kitties can still live long and happy lives. Here is what the WCRAS says about Romeo on their website:
"Romeo is a total sweetheart! He is friendly and affectionate and loves everybody. He was found wandering around lost so he is really wishing and hoping for someone nice to come and rescue him. Romeo has FIV (Feline Immunodeficiency Virus), but that is not a death sentence. With proper care and nutrition, he can live a long and healthy life. It is not contagious to dogs or people, and only transmitted to other cats through biting. If you are looking for the love of your life, who will be your only cat, Romeo is the one for you!"
Doesn't he just sound wonderful?! You can learn more about Romeo at his details page here. If you're interested in adopting Romeo, please visit the WCRAS website for more information!

Opt to Adopt! Dogs N Pawz hosts a weekly adoption Blog Hop - visit the links below to find more adoptable pets!?

Source: http://www.mypawsitivelypets.com/2013/06/romeo-adoptable-cat-in-texas-needs.html

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শনিবার, ১৮ মে, ২০১৩

U.S. authorities seize accounts of major Bitcoin operator

By Brett Wolf

ST. LOUIS, May 17 (Thomson Reuters Accelus) - U.S. authorities have seized two accounts linked to a major operator in the booming Bitcoin digital currency market, Tokyo-based exchange Mt. Gox. The move may prevent the firm from facilitating the purchase and sale of Bitcoins in U.S. dollars at a time when use of the currency and its value has mushroomed.

Bitcoin, which unlike conventional money is bought and sold on a peer-to-peer network independent of any central authority, has grown popular among users who lack faith in the established banking system.

The price of the volatile currency ballooned in March as a result of the Cyprus bank crisis. Authorities worry that a lack of regulation has left the currency vulnerable to money launderers and other criminals.

A seizure warrant obtained Tuesday by the Department of Homeland Security froze an account that an Iowa-based online payment processor, Dwolla Inc, held at Veridian Credit Union in the name of Mutum Sigillum LLC.

An affidavit filed by an agent with the department's investigations unit states that Mutum Sigillum, a Mt. Gox subsidiary incorporated in Delaware, was operating as an unlicensed money transmitter, in violation of federal law.

Treasury's anti-money laundering unit, the Financial Crimes Enforcement Network (FinCEN), in March issued guidance that dubbed digital currency exchanges money transmitters, a finding that obliged such businesses to register with FinCEN and obtain any mandated state licenses.

A search of FinCEN's online registration database Friday morning suggested that neither Mt. Gox nor Mutum Sigillum had registered. The affidavit cited Mutum Sigillum's failure to register with FinCEN as sufficient grounds to seize its accounts.

Both Mutum Sigillum and Mt. Gox, which says it handles 80 percent of Bitcoin trading, are owned by Mark Karpeles, the affidavit states. It adds that Karpeles opened an account in Mutum Sigillum's name at Wells Fargo in May 2011, and that when doing so completed a form in which he said it was not a money transmitter.

Karpeles did not immediately respond to a request for comment. Nor did Dwolla.

The Wells Fargo account was seized earlier this month as part of the same investigation that prompted the seizure of Mutum Sigillum's Dwolla account at Veridian Credit Union, the affidavit states.

It also notes that those wishing to use U.S. dollars to buy Bitcoins deposited money with Dwolla and directed that it be forwarded to Mt. Gox. When people wanted to cash out, Mt. Gox wired funds from an account at Sumitomo Mitsui Bank in Japan to the Wells Fargo account and U.S. dollars were sent to Dwolla.

An Homeland Security department informant based in Maryland engaged in such transactions, the affidavit states, presenting the informant's Bitcoin exchanges as evidence of Mutum Sigillum's purported status as a money transfer firm.

The seizure of the Mt. Gox-linked accounts may threaten the exchange's ability to do business in U.S. dollars. The impact on the overall Bitcoin market is unclear.

Some Mt. Gox customers have already taken to message boards to express concern about their ability to buy Bitcoins with U.S. dollars or liquidate existing investments. One user posting on a Bitcoin question and answer site suggested this problem was a grave one for the currency and Mt. Gox.

"Most of the trading volume is in dollars at Gox if I'm not mistaken, so this might be the death blow for them," the user's post stated.

Thomson Reuters' Compliance Complete reported last month that Karpeles said all of Mt. Gox's U.S.-dollar activity was accomplished via a Dwolla account.

When Compliance Complete asked at the time whether Mt. Gox had registered with FinCEN in the wake of the March guidance, Karpeles said that it had not, but that it planned to do so. He added that Mt. Gox and Dwolla were "discussing compliance issues on a regular basis."

A spokeswoman for Homeland Security declined to comment on whether the agency, or any foreign law enforcement agency with which it may be cooperating, plan to seize any other accounts linked to Karpeles, Mt. Gox, or other Bitcoin exchanges.

(This article was produced by the Compliance Complete service of Thomson Reuters Accelus. Compliance Complete (http://bit.ly/16Ebxub) provides a single source for regulatory news, analysis, rules and developments, with global coverage of more than 230 regulators and exchanges. Follow Accelus compliance news on Twitter: @GRC_Accelus)

(Editing by Randall Mikkelsen and Phil Berlowitz)

Source: http://news.yahoo.com/u-authorities-seize-accounts-major-bitcoin-operator-163408866.html

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শনিবার, ৪ মে, ২০১৩

Toys R Us appeals $20M award in Mass. slide death (Providence Journal)

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96% War Witch

All Critics (47) | Top Critics (16) | Fresh (45) | Rotten (2)

Canadian writer-director Kim Nguyen spent nearly a decade researching this docudrama about child soldiers in Africa, and the film feels as authoritative as a first-hand account.

A haunting take on unspeakably grim subject matter, shot on location in the Democratic Republic of Congo.

A powerful and upsetting portrait of a young girl compelled into unimaginably horrific circumstances.

Nguyen, astonishingly, manages to wring something vaguely like a happy ending from this tragic story.

War Witch is most effective not when we are looking in on Komona but when we are inside her head.

The powerful things we expect from "War Witch" are as advertised, but what we don't expect is even better.

... driven by a remarkably natural, unaffected performance by Mwanza. And Nguyen, despite relying a little too heavily on the initial voice-over for exposition, is a confident and sensitive intelligence behind the camera.

You're likely to ponder its images, its insights into a very foreign (for most of us) location and the tragic situation of Komona (and others like her) for a long time to come.

Is it accurate depiction of Africa's child soldiers? I don't know, thank God. But it feels authentic to its very core, and that makes it as hard to forget as it is to ignore.

Brutal without turning exploitative, the result is harrowing and heartbreaking.

Nguyen creates a mesmerizing tone through his camerawork, editing, sound and the infusion of African folk imagery and ritual, but it's Mwanza's performance as Komona that makes "War Witch" feel so miraculous.

Nguyen reportedly worked on "War Witch" for a decade, and it shows in both the immediacy and authenticity of his tale, and the meticulous craft with which it's told.

Made with extremely clear-eyed restraint from harangues, sentiment, message-mongering, or anything else that would cheapen its central character's suffering and fight.

War Witch features a standout performance by Rachel Mwanza, but the supernatural visions don't really suit the film's tone and mood.

Nguyen's compassion and commitment to the issue is admirable, and at its best, War Witch is devastating.

War Witch is remarkable for the fact that it never strays into sentimentality or sensationalism.

...a love story between youngsters who are forced to become adults all too early in their lives.

This is a straight ahead essay on warfare at its worst and the survival of the human spirit at its best.

An astonishing drama set in Africa that vividly depicts the courage and resiliency of a 12-year-old girl whose spiritual gifts enable her to survive.

It is astonishing that film that contains such violence can have such a serene tone. The source of the serenity is the measured, calm narration by Komona (voice of Diane Umawahoro) that is the telling of her story to her unborn child

An exquisitely made film in direct contrast to the ugliness of its subject matter

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Source: http://www.rottentomatoes.com/m/war_witch/

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Researchers discover new target for personalized cancer therapy

Friday, May 3, 2013

A common cancer pathway causing tumor growth is now being targeted by a number of new cancer drugs and shows promising results. A team of researchers at Case Western Reserve University School of Medicine have developed a novel method to disrupt this growth signaling pathway, with findings that suggest a new treatment for breast, colon, melanoma and other cancers.

The research team has pinpointed the cancer abnormality to a mutation in a gene called PIK3CA that results in a mutant protein, which may be an early cancer switch. By disrupting the mutated signaling pathway, the Case Western Reserve team, led by John Wang, PhD, inhibited the growth of cancer cells, opening the possibility to new cancer therapies.

Their findings, "Gain of interaction with IRS1 by p110? helical domain mutants is crucial for their oncogenic functions," was published on May 2 in the journal Cancer Cell.

Cancer arises from a single cell, which has mutated in a small number of genes because of random errors in the DNA replication process. These mutations play key roles in carcinogenesis.

"This discovery has a broad impact on the treatment of human cancer patients because so many cancers are affected by this particular mutation in the p110? protein, which is encoded by the PIK3CA gene," said Wang, an associate professor in the Department of Genetics and Case Comprehensive Cancer Center. "This is a significant advance because we can now disrupt this misdirected signaling pathway in cancer cells."

"If you turn on a light, you have to turn on a switch. But in the case of the mutation of this protein, p110? turns on by itself," Wang said. "The mutation rewires the circuit and is uncontrolled. This implies that if you break these wires, you can control the growth of cancer. Our current discovery may lead to finding less toxic drugs that can be used for personalized treatment for cancer patients in the future."

"This research will impact the field by focusing us on new targets for treating and preventing metastasis in patients in a many different types of human cancers," said Stanton Gerson, MD, Asa and Patricia Shiverick-Jane Shiverick (Tripp) Professor of Hematological Oncology, and director of Case Comprehensive Cancer Center and of Seidman Cancer Center at University Hospitals Case Medical Center.

Wang's multidisciplinary team of Case Western Reserve researchers includes: Yujun Hao, Chao Wang, Bo Cao, Brett M. Hirsch, Jing Song, Sanford D. Markowitz, Rob M. Ewing, David Sedwick, Lili Liu and Weiping Zheng.

###

Case Western Reserve University: http://www.case.edu

Thanks to Case Western Reserve University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/128122/Researchers_discover_new_target_for_personalized_cancer_therapy

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শুক্রবার, ৩ মে, ২০১৩

Why You Should Buy Commercial Property For Your Business

It?s harder to find commercial properties. Although there are plenty of commercial investments in the market, these buildings don?t get preferential listings in classified ads or real estate catalogs as do residential listings. You have to search for the best possible deals to find the best options for your investment. This article will provide you with all the pertinent information.

Make sure that you invest some time researching local income levels and other factors, such as unemployment rates or local employers plans for expanding or contracting their businesses before you invest a large amount of funds into real estate. Property that is located near a large business, a college, or a hospital has better resale value and will often sell easier.

TIP! Whether buying or selling, negotiate. You should make sure that they hear you and you get the fairest price for your property.

Before you sign a lease, find out about pest control. If you are renting a space that has known vermin problems, be sure to find out exactly who is responsible for pest control.

Commercial transactions are significantly more time-consuming, complex and involved than the home-buying process. Remember that the time and efforts you are investing will pay off.

One major part of commercial real estate deals is inspections. When property you are involved in is being inspected, take steps to verify the legitimacy of every inspector. Many people in certain fields are not accredited, including pest and insect removal services. This will avoid bigger problems in the post-sale.

TIP! Calm and patience are both sound practices when you are searching for commercial property. Do not rush into making quick real estate decisions.

If you have the intention of offering your commercial real estate for rent, look for buildings that are simple and solid in construction. These are the most likely to quickly invite tenants into the space, because they know it is well-cared for. These types of buildings are easier to fix for everyone and they might not need as many fixes.

Ensure there is adequate access to utilities on the commercial property. Water and sewer access will be needed in addition to electricity. You may want the option to use natural gas, as well.

Know your needs before you even start looking for a commercial real estate. Write down the features of a piece of property that are the most essential to you, such as how many square feet it must be and the number of specific rooms it should have, including conference rooms, offices, and restrooms.

TIP! Initially, your investment will take up a great deal of your time. It takes time to find a lucrative opportunity and purchase a propriety, adding to that time to carry out any repairs and alterations that are needed.

Commercial real estate has many brokers to offer. Some are full service brokers, and they work on behalf of landlords and tenants. Others are agents who represent only tenants. It might be most beneficial for you to hire a broker who works exclusively with tenants. A broker with that focus will be more experienced in successful dealings with tenants.

Speak to a tax adviser prior to buying a property. The tax lawyer will help you find out how much it will cost you and how much you will be taxed. Consult your adviser for areas where taxes are lower.

Prior to selecting a real estate broker, determine what kind of negotiating tactics they have. Inquire about their training and experience. You?ll also want an agent that conducts themselves professionally and ethically, and who has expertise in closing beneficial deals. Request additional information or examples of the results from previous negotiations.

TIP! Net Operating Income, the commercial metric for real estate, needs to be understood. To be successful, you must stay profitable.

Look around at the general environment around the building. You?ll be liable for cleaning up after environmental incidents. Are you aware of whether or not the property is located on a flood plain? You may need to think again. There are environmental assessment organizations who can provide information about a specific area if you contact them.

Make certain to think about any sorts of environmental issues. A thing that people are often worried about is that your commercial property may have hazardous waste problems. It?s up to you to be aware of the issues, fix them, and have them inspected once complete.

A large commercial property may be a better buy than a smaller one. If you were considering purchasing a building that has ten units, keep in mind that it does not involve that much more work to manage 75 units instead. A small building requires the same paperwork and financing as a larger building, and larger buildings end up costing less per unit.

TIP! You should be certain that your asking price is a fair offer for your piece of real estate. There are a lot of factors that determine the value of the lot.

Once you are sure which commercial property you want to choose, you are by no means finished. There is still so much more to do, and to learn. Gaining even a little bit of knowledge about commercial real estate helps you make better decisions.

Source: http://www.maynaseric.com/why-you-should-buy-commercial-property-for-your-business-3

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The Day In 100 Seconds (talking-points-memo)

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